Advanced Supplemental Therapies

Enzymes Blog
Fibrin, Scar Tissue and Serrapeptase

Fibrin is an essential protein in the human body that is produced during inflammation. The body utilizes fibrin as a blood clotting protein, containing blood loss and keeping infection at bay, especially after an injury. Fibrin accumulation is one of the first steps in the body’s attempt to recover. 

Scar tissue is fibrous, connective tissue – made primarily of fibrin – which the body uses to replace previously healthy tissue that has been destroyed by injury or disease. Under normal conditions, scar tissue should be the final result during typical inflammatory response.

However, when inflammation has become prolonged – fibrin, along with other proteins such as collagen, can begin to transform original soft tissue into a tough fibrous matrix.  Differentiated and sequestered apart from healthy tissue, this fibrous matrix still maintains the biological markers of inflammation, such as swelling, redness and pain.  And as long as this kind of inflammation persists, nutrients and other chemical building blocks are still needed for healthy cells and tissue.

Serrapeptase has Greater Activity than Trypsin, Chymotrypsin and Asprin

A team of researchers has revealed strong evidence that various proteolytic enzymes – specifically trypsin, chymotrypsin and serratiopeptidase (serrapeptase) – can significantly reduce various states of inflammation. Investigators looked both at the activity when enzymes are taken alone, as well as in low doses with aspirin.

To conduct their study, the team used rat models with experimentally produced acute and sub-acute inflammation. Acute inflammation was induced by injecting carrageenan, a gelatinous extract from seaweed, in the right hind paw of the animal to simulate edema. Sub-acute inflammation was produced by implanting cotton pellets subcutaneously, or just under the skin, forming a granuloma.

Animals were treated with aspirin, proteolytic enzymes alone in three different doses, an enzyme-aspirin combination, or with saline as the control. Treatment was administered 30 minutes prior to inducing inflammation and was repeated once daily for 10 days.

Researchers assessed the level of edema produced by the injection by measuring the change in volume of the paw. Serrapeptase showed greater anti-inflammatory activity on acute inflammation than trypsin, chymotrypsin and aspirin.