Advanced Supplemental Therapies

How to Choose Quality Systemic Enzymes

All enzyme supplements are not the same. Quality, efficacy and activity are important factors to consider when selecting systemic enzyme products. High quality enzyme products should be assessed based on the following standards.

Systemic Enzymes are NOT Digestive Enzymes

Digestive enzyme supplements are designed to be taken with each meal to complement the body’s own enzyme production to help break down food. Systemic enzymes are designed to be taken on an empty stomach so they can bypass gastric acid digestion and enter the intestinal tract. Here, systemic enzymes can be absorbed intact into the bloodstream.

Plant-based and Microbial Enzymes vs. Animal-based Enzymes

Systemic enzymes can be extracted from plant, microbial, and animal sources. Plant-based enzymes are active in a broad range of pH, which means they remain stable throughout the intestinal tract. Most enzyme supplements are extracted from natural fermentation of microbes such as bacteria, which have a narrower optimal pH range that is maintained by enteric coating. Microbial enzymes are more practical to produce and the enzyme content is easier to control. These enzymes are suited for vegetarians and do not interfere with the natural functioning of the body and therefore have no side effects. In contrast, animal-based enzymes work only in a narrow range of pH and can easily be destroyed by stomach acid.

Enteric coated Serrapeptase

Most serrapeptase supplements are not enteric coated, which means they can lose a significant portion of their fibrinolytic activity and effectiveness in the acidic environment of the stomach. The enteric coating allows these sensitive enzymes to survive the acidic conditions of the stomach, thus allowing them to pass into the blood at higher levels. The pH resistant enteric coating will disintegrate after it enters the alkaline environment of the intestines. If an enzyme formula is not enteric coated, it may be a waste of money.

Blends of Systemic Enzymes

Although each enzyme has its own specific function in the body, they tend to work synergistically when taken in combination. Because of their variety of origins and substrates, wide ranges of optimal temperatures and pH levels, increased percentage of absorption, and increased level of effectiveness, enzyme blends have a wider range of advantages than do individual enzymes. Additionally, when enzymes are taken in combination with vitamins, minerals, herbs or phytonutrients (naturally occurring nutrients found in plants) the combination improves absorption and bioavailability of the ingredients.

Activity vs. Milligrams

Unlike other supplements, the weight (mg) of an enzyme supplement carries no significance. It is not the amount but the potency, or activity, of the enzyme that really matters. Guaranteeing the ingredients are available to the body is more important than how much of a nutrient is listed on a supplement label.

Capsule vs. Tablet

Enzymes in capsule form are more available to the body than tablets. Tablets often have binding agents and a protective coating that make it difficult for the body to absorb the enzymes. Also, the processing techniques used to make tablets require extreme pressure to compress the ingredients, creating friction and high temperatures that can destroy the enzymes rendering them useless to the body. Capsules are created under much milder conditions allowing the enzymes to stay intact and remain available to the body.

Prebiotic and Probiotic Blends

Oral supplementation of common Lactobacilli and Bifidobacteria species have a good safety profile and are well tolerated, as evidenced throughout studies in which they were used up to one year and longer. There are no known drug interactions with these probiotic species. For additional health benefits, probiotic products are best when combined with “prebiotics,” such as fructooligosaccharides (FOS), galactooligosaccharides and inulin. When probiotics are combined with prebiotics, the resulting supplement is called a synbiotic. Prebiotics promote the growth and activity of probiotic bacteria. FOS particularly may even help relieve constipation by increasing fecal mass. Given the many benefits of the various probiotic species, it makes perfect sense to provide a comprehensive blend of many different species that will then provide the best attributes of each in a single probiotic supplement.